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Men with early-stage prostate cancer may be able to inhibit tumour growth and progression by following a high-fibre diet, according to recent study results.
The research focused on inositol hexaphosphate (IP6), a major constituent of high-fibre diets. Prostate cancer occurs at similar rates in Asian and in Western cultures, yet tends to progress in the latter but not in the former. Asian diets are high in IP6, whereas Western culture diets generally are not, explained study coauthor Komal Raina, PhD, of the University of Colorado Cancer Center in Aurora, Colorado, in a statement issued by the facility.
Raina’s team fed mice with transgenic adenocarcinoma of the prostate with 1%, 2%, or 4% IP6 in drinking water from age 4 weeks until age 28 weeks. Control mice received plain water.
Magnetic resonance imaging (MRI) showed a profound reduction in tumor size among the mice in the IP6 group, wrote Raina and colleagues in Cancer Prevention Research (2013;6:40-50). IP6 also significantly decreased membrane phospholipid synthesis and glucose metabolism.
“The study’s results were really rather profound,” Raina emphasized. “We saw dramatically reduced tumor volumes, primarily due to the antiangiogenic effects of IP6.”
Raina’s team concluded that oral IP6 supplement blocks growth and angiogenesis of prostate cancer in transgenic adenocarcinoma of the mouse prostate in conjunction with metabolic events involved in tumor sustenance. This results in energy deprivation within the tumor, suggesting that IP6 has the potential to suppress growth and progression of human prostate cancer.
Soy and tomato foods are probably better at preventing prostate cancer when eaten in combination than alone, researchers from the University of Illinois reported this week.
How much soy and tomato should I eat to help prevent cancer? Zuniga says that the results of the mouse study suggest a 55-year-old male who wants to reduce his risk of developing prostate cancer should consume: 3 to 4 servings of tomato products per week 1 or 2 servings of soy foods per day The scientists emphasized that their findings also reinforce the recommendation that people should make sure their diets contain a wide range of whole fruits and vegetables.
“It’s better to eat a whole tomato than to take a lycopene supplement. It’s better to drink soy milk than to take soy isoflavones. When you eat whole foods, you expose yourself to the entire array of cancer-fighting, bioactive components in these foods.”
Early screening for prostate cancer could become as easy for men as personal pregnancy testing is for women, thanks to UC Irvine research published in the /i>Journal of the American Chemical Society.
After more than a decade of work, UC Irvine chemists have created a way to clearly identify clinically usable markers for prostate cancer in urine, meaning that the disease could be detected far sooner, with greater accuracy and at dramatically lower cost. The same technology could potentially be used for bladder and multiple myeloma cancers, which also shed identifiable markers in urine.
“Our goal is a device the size of a home pregnancy test priced around $10. You would buy it at the drugstore or the grocery store and test yourself,” said the study’s corresponding author, Reginald Penner, UC Irvine Chancellor’s Professor of chemistry. “We’re on the verge of a very important breakthrough in a new era of personal health management.”
Abiraterone was designed and developed at The Institute of Cancer Research (ICR) and The Royal Marsden Hospital. First synthesised in the early 1990s, this year it completed the journey from an idea to life-extending treatment for men with advanced prostate cancer. The US Food and Drug administration (FDA) approved the use of abiraterone in men with castration resistant prostate cancer in April 2011, and European approval followed in September 2011.
Abiraterone has not only led to improved survival in men with advanced prostate cancer but has also changed the way we think about this disease. Lead researchers Professor Mike Jarman, Dr Elaine Barrie, Professor Gerry Potter, Professor Ian Judson, Professor Johann de Bono and Dr Florence Raynaud were recognised with the Royal Society of Chemistry?s prestigious Teamwork and Innovation Award, announced in May 2011, for their contributions to developing this important treatment
The ultimate goal is to prevent men from developing prostate cancer. Although significant progress has been made and genetic and environmental risk factors for prostate cancer have been identified, the evidence is not strong enough for conclusive recommendations.
American Society of Clinical Oncology (ASCO)
In recent years, there has been an adjustment in the scientific thinking about the utility of screening men for prostate cancer using prostate-specific antigen (PSA). That shift has been slow to occur in daily practice as a result, in part, of a feeling among the health care community that there is still not a clear answer to the question: Which, if any, men should be screened for prostate cancer?
MEN who eat more healthy fats from vegetables, nuts and olive oil after a diagnosis of prostate cancer see better survival rates than peers whose diets are unchanged, a US study says.
The findings in the Journal of the American Medical Association (JAMA) Internal Medicine on Monday suggest that dietary improvements can be an important way to lower the death risk among men whose prostate cancer has not spread.
“Consumption of healthy oils and nuts increases plasma antioxidants and reduces insulin and inflammation, which may deter prostate cancer progression,” said lead author Erin Richman, a postdoctoral scholar in the University of California San Francisco Department of Epidemiology and Biostatistics.